Cancer-associated fibroblast suppresses killing activity of natural killer cells through downregulation of poliovirus receptor (PVR/CD155), a ligand of activating NK receptor

Cancer-associated fibroblasts (CAFs) play an important role in cancer expansion and progression in tumor microenvironment (TME), via both direct and indirect interactions. Natural killer (NK) cells play a crucial role in anticancer immunity. We investigated the inhibitory effects of CAFs on NK cell...

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Udgivet i:Int J Oncol
Main Authors: Inoue, Tomoko, Adachi, Katsuyuki, Kawana, Kei, Taguchi, Ayumi, Nagamatsu, Takeshi, Fujimoto, Asaha, Tomio, Kensuke, Yamashita, Aki, Eguchi, Satoko, Nishida, Haruka, Nakamura, Hiroe, Sato, Masakazu, Yoshida, Mitsuyo, Arimoto, Takahide, Wada-Hiraike, Osamu, Oda, Katsutoshi, Osuga, Yutaka, Fujii, Tomoyuki
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021244/
https://ncbi.nlm.nih.gov/pubmed/27499237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2016.3631
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