Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Sp1.

We have overexpressed and purified two peptide fragments of Sp1 that contain the three "zinc-finger" domains necessary for specific Sp1 DNA binding. These peptides assume a stable, folded conformation in solution in the presence of Zn2+ as shown by DNA binding assays and NMR spectroscopy. Mobility-s...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kriwacki, R W, Schultz, S C, Steitz, T A, Caradonna, J P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50212/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1329106/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.20.9759
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