LIGHT/IFN‐γ triggers β cells apoptosis via NF‐κB/Bcl2‐dependent mitochondrial pathway

LIGHT recruits and activates naive T cells in the islets at the onset of diabetes. IFN‐γ secreted by activated T lymphocytes is involved in beta cell apoptosis. However, whether LIGHT sensitizes IFNγ‐induced beta cells destruction remains unclear. In this study, we used the murine beta cell line MIN...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Zheng, Quan‐You, Cao, Zhao‐Hui, Hu, Xiao‐Bo, Li, Gui‐Qing, Dong, Shi‐Fang, Xu, Gui‐Lian, Zhang, Ke‐Qin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020636/
https://ncbi.nlm.nih.gov/pubmed/27241100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12876
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