STAT1-Mediated Down-Regulation of Bcl-2 Expression Is Involved in IFN-γ/TNF-α–Induced Apoptosis in NIT-1 Cells

Tumor necrosis factor (TNF)-α and interferon (IFN)-γ are the major pro-inflammatory cytokines involved in beta-cell destruction. The fate of islet beta-cells in the cytokine-induced intrinsic mitochondrial apoptotic pathway is determined by the interaction between members of the Bcl-2 family. Howeve...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cao, Zhao-hui, Zheng, Quan-you, Li, Gui-qing, Hu, Xiao-bo, Feng, Shao-long, Xu, Gui-lian, Zhang, Ke-qin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374929/
https://ncbi.nlm.nih.gov/pubmed/25811609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120921
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