Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets

BACKGROUND: Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of platelets to the vascular wall. α(IIb)β(3) is the main integrin responsible for platelet activation and Rap1b plays a key role in i...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Benz, Peter M., Laban, Hebatullah, Zink, Joana, Günther, Lea, Walter, Ulrich, Gambaryan, Stepan, Dib, Karim
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020514/
https://ncbi.nlm.nih.gov/pubmed/27620165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-016-0144-z
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