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Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice
Endogenously administered activated protein C ameliorates diabetic nephropathy (DN) in a protease-activated receptor-1 (PAR-1)-dependent manner, suggesting that PAR-1 activation limits the progression of DN. Activation of PAR-1 in fibroblast-like cells, however, induces proliferation and extracellul...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5020504/ https://ncbi.nlm.nih.gov/pubmed/27618774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33030 |
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