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The legacy of the F344 rat as a cancer bioassay model (a retrospective summary of three common F344 rat neoplasms)

The Fischer 344 (F344) rat was used by the National Toxicology Program (NTP) for over 5 decades for toxicity and carcinogenicity studies. However, in 2006, the NTP decided to switch to a different rat stock due largely to high background control incidences of Leydig cell tumors (LCTs) and mononuclea...

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Detalhes bibliográficos
Publicado no:Crit Rev Toxicol
Main Authors: Maronpot, Robert R., Nyska, Abraham, Foreman, Jennifer E., Ramot, Yuval
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020328/
https://ncbi.nlm.nih.gov/pubmed/27278595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10408444.2016.1174669
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