Gain-of-Function Alleles in Caenorhabditis elegans Nuclear Hormone Receptor nhr-49 Are Functionally Distinct

Nuclear hormone receptors (NHRs) are transcription factors that regulate numerous physiological and developmental processes and represent important drug targets. NHR-49, an ortholog of Hepatocyte Nuclear Factor 4 (HNF4), has emerged as a key regulator of lipid metabolism and life span in the nematod...

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Vydáno v:PLoS One
Hlavní autoři: Lee, Kayoung, Goh, Grace Ying Shyen, Wong, Marcus Andrew, Klassen, Tara Leah, Taubert, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019492/
https://ncbi.nlm.nih.gov/pubmed/27618178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162708
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