Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies

Chronic cholangiopathies, such as primary and secondary sclerosing cholangitis, are progressive disease entities, associated with periportal accumulation of inflammatory cells, encompassing monocytes and macrophages, peribiliary extracellular matrix (ECM) deposition and ductular reaction (DR). This...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Best, Jan, Verhulst, Stefaan, Syn, Wing-Kin, Lagaisse, Kimberly, van Hul, Noemi, Heindryckx, Femke, Sowa, Jan-Peter, Peeters, Liesbeth, Van Vlierberghe, Hans, Leclercq, Isabelle A., Canbay, Ali, Dollé, Laurent, van Grunsven, Leo A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019458/
https://ncbi.nlm.nih.gov/pubmed/27618307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162286
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