Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies

Chronic cholangiopathies, such as primary and secondary sclerosing cholangitis, are progressive disease entities, associated with periportal accumulation of inflammatory cells, encompassing monocytes and macrophages, peribiliary extracellular matrix (ECM) deposition and ductular reaction (DR). This...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Best, Jan, Verhulst, Stefaan, Syn, Wing-Kin, Lagaisse, Kimberly, van Hul, Noemi, Heindryckx, Femke, Sowa, Jan-Peter, Peeters, Liesbeth, Van Vlierberghe, Hans, Leclercq, Isabelle A., Canbay, Ali, Dollé, Laurent, van Grunsven, Leo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019458/
https://ncbi.nlm.nih.gov/pubmed/27618307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162286
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