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Quinolone binding to DNA is mediated by magnesium ions.

The binding of plasmid DNA to norfloxacin, a quinolone antibacterial agent, was investigated by fluorescence, electrophoretic DNA unwinding, and affinity chromatography techniques. The amount of quinolone bound to DNA was modulated by the concentration of Mg2+. No interaction was evident in the abse...

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Détails bibliographiques
Auteurs principaux: Palù, G, Valisena, S, Ciarrocchi, G, Gatto, B, Palumbo, M
Format: Artigo
Langue:Inglês
Publié: 1992
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC50194/
https://ncbi.nlm.nih.gov/pubmed/1409681
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