Simple modifications to Methimazole that enhance its inhibitory effect on Tumor Necrosis Factor-α-induced Vascular Cell Adhesion Molecule-1 expression by human endothelial cells

The expression of vascular cell adhesion molecule-1 (VCAM-1) on the vascular endothelium can be increased by pro-inflammatory cytokines [e.g. tumor necrosis factor – α (TNF-α)]. VCAM-1 contributes to leukocyte adhesion to, and emigration from, the vasculature which is a key aspect of pathological in...

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Pubblicato in:Eur J Pharmacol
Autori principali: Alapati, Anuja, Deosarkar, Sudhir P., Lanier, Olivia L., Qi, Chunyan, Carlson, Grady E., Burdick, Monica M., Schwartz, Frank L., McCall, Kelly D., Bergmeier, Stephen C., Goetz, Douglas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019189/
https://ncbi.nlm.nih.gov/pubmed/25641748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2015.01.032
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