Phenylmethimazole and a thiazole derivative of phenylmethimazole inhibit IL-6 expression by triple negative breast cancer cells

Inhibition of interleukin–6 (IL-6) holds significant promise as a therapeutic approach for triple negative breast cancer (TNBC). We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. We have identified a more potent derivative of C10 termed COB-141...

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Pubblicato in:Eur J Pharmacol
Autori principali: Noori, Mahboubeh S., O'Brien, John D., Champa, Zachary J., Deosarkar, Sudhir P., Lanier, Olivia L., Qi, Chunyan, Burdick, Monica M., Schwartz, Frank L., Bergmeier, Stephen C., McCall, Kelly D., Goetz, Douglas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461878/
https://ncbi.nlm.nih.gov/pubmed/28343970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2017.03.049
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