Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I(Kur) Inhibitor

[Image: see text] A new series of phenylquinazoline inhibitors of K(v) 1.5 is disclosed. The series was optimized for K(v) 1.5 potency, selectivity versus hERG, pharmacokinetic exposure, and pharmacodynamic potency. 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine (13k) was ident...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Finlay, Heather J., Johnson, James A., Lloyd, John L., Jiang, Ji, Neels, James, Gunaga, Prashantha, Banerjee, Abhisek, Dhondi, Naveen, Chimalakonda, Anjaneya, Mandlekar, Sandhya, Conder, Mary Lee, Sale, Harinath, Xing, Dezhi, Levesque, Paul, Wexler, Ruth R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018869/
https://ncbi.nlm.nih.gov/pubmed/27660686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00117
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