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GlyT2-Dependent Preservation of MECP2-Expression in Inhibitory Neurons Improves Early Respiratory Symptoms but Does Not Rescue Survival in a Mouse Model of Rett Syndrome

Mutations in methyl-CpG-binding protein 2 (MECP2) gene have been shown to manifest in a neurodevelopmental disorder that is called Rett syndrome. A typical problem that occurs during development is a disturbance of breathing. To address the role of inhibitory neurons, we generated a mouse line that...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Hülsmann, Swen, Mesuret, Guillaume, Dannenberg, Julia, Arnoldt, Mauricio, Niebert, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018520/
https://ncbi.nlm.nih.gov/pubmed/27672368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00385
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