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Sensitive methods for screening of the MEK1 gene mutations in patients with central nervous system metastases of non-small cell lung cancer

BACKGROUND: The mitogen-activated protein kinases 1 and 2 (MEK1, MEK2) are fundamental partners in the RAS–RAF–MEK–ERK pathway that is involved in regulation of cell proliferation, differentiation and survival. Downregulation of the MEK cascades has been implicated in acquiring of the malignant phen...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Transl Oncol
Prif Awduron: Nicoś, M., Krawczyk, P., Jarosz, B., Sawicki, M., Michnar, M., Trojanowski, T., Milanowski, J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer International Publishing 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018022/
https://ncbi.nlm.nih.gov/pubmed/26860843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12094-016-1483-3
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