A Genome-Wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

Apicomplexan parasites are leading causes of human and livestock diseases—like malaria and toxoplasmosis—yet most of their genes remain uncharacterized. Here, we present the first genome-wide genetic screen of an apicomplexan. We adapted CRISPR/Cas9 to assess the contribution of each gene from the h...

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Vydáno v:Cell
Hlavní autoři: Sidik, Saima M., Huet, Diego, Ganesan, Suresh M., Huynh, My-Hang, Wang, Tim, Nasamu, Armiyaw S., Thiru, Prathapan, Saeij, Jeroen P.J., Carruthers, Vern B., Niles, Jacquin C., Lourido, Sebastian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017925/
https://ncbi.nlm.nih.gov/pubmed/27594426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.019
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