γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

Inflammation is paramount in pancreatic oncogenesis. We identified a uniquely-activated γδT cell population which constituted ∼40% of tumor-infiltrating T cells in human pancreatic ductal adenocarcinoma (PDA). Recruitment and activation of γδT cells was contingent on diverse chemokine signals. Delet...

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Publicat a:Cell
Autors principals: Daley, Donnele, Zambirinis, Constantinos, Seifert, Lena, Akkad, Neha, Mohan, Navyatha, Werba, Gregor, Barilla, Rocky, Torres-Hernandez, Alejandro, Hundeyin, Mautin, Kumar Mani, Vishnu Raj, Avanzi, Antonina, Tippens, Daniel, Narayanan, Rajkishen, Jang, Jung-Eun, Newman, Elliot, Pillarisetty, Venu Gopal, Dustin, Michael Loran, Bar-Sagi, Dafna, Hajdu, Cristina, Miller, George
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017923/
https://ncbi.nlm.nih.gov/pubmed/27569912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.07.046
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