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Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington’s Disease Patients

Metabolic dysfunction is well-documented in Huntington’s disease (HD). However, the link between the mutant huntingtin (mHTT) gene and the pathology is unknown. The tricarboxylic acid (TCA) cycle is the main metabolic pathway for the production of NADH for conversion to ATP via the electron transpor...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Naseri, Nima N., Bonica, Joseph, Xu, Hui, Park, Larry C., Arjomand, Jamshid, Chen, Zhengming, Gibson, Gary E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017661/
https://ncbi.nlm.nih.gov/pubmed/27611087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160384
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