The Role of the Rho/ROCK Pathway in Ang II and TGF-β1-Induced Atrial Remodeling

OBJECTIVES: To study the role of the Rho/ROCK pathway in Ang II and TGF-β1-induced atrial remodeling. METHODS AND RESULTS: A canine atrial fibrillation (AF) model was established by rapid atrial pacing (RAP) of the left atrium. The roles of TGF-β1, the RhoA/ROCK signaling pathway and connective tiss...

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Veröffentlicht in:PLoS One
Hauptverfasser: Liu, Li-Juan, Yao, Feng-Juan, Lu, Gui-Hua, Xu, Cheng-Gui, Xu, Zhe, Tang, Kai, Cheng, Yun-Jiu, Gao, Xiu-Ren, Wu, Su-Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017578/
https://ncbi.nlm.nih.gov/pubmed/27611832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161625
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