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MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells

The efficiency of pluripotent stem cell differentiation is highly variable, often resulting in heterogeneous populations that contain undifferentiated cells. Here we developed a sensitive, target-specific, and general method for removing undesired cells before transplantation. MicroRNA-302a-5p (miR-...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Parr, Callum J. C., Katayama, Shota, Miki, Kenji, Kuang, Yi, Yoshida, Yoshinori, Morizane, Asuka, Takahashi, Jun, Yamanaka, Shinya, Saito, Hirohide
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016789/
https://ncbi.nlm.nih.gov/pubmed/27608814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32532
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