N (1)-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells

Synthetic messenger RNA (mRNA) tools often use pseudouridine and 5-methyl cytidine as substitutions for uridine and cytidine to avoid the immune response and cytotoxicity induced by introducing mRNA into cells. However, the influence of base modifications on the functionality of the RNA tools is poo...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Parr, Callum J C, Wada, Shunsuke, Kotake, Kenjiro, Kameda, Shigetoshi, Matsuura, Satoshi, Sakashita, Souhei, Park, Soyoung, Sugiyama, Hiroshi, Kuang, Yi, Saito, Hirohide
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Synthetic Biology and Bioengineering
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102939/
https://ncbi.nlm.nih.gov/pubmed/32090264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa070
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker