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MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells

The efficiency of pluripotent stem cell differentiation is highly variable, often resulting in heterogeneous populations that contain undifferentiated cells. Here we developed a sensitive, target-specific, and general method for removing undesired cells before transplantation. MicroRNA-302a-5p (miR-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Parr, Callum J. C., Katayama, Shota, Miki, Kenji, Kuang, Yi, Yoshida, Yoshinori, Morizane, Asuka, Takahashi, Jun, Yamanaka, Shinya, Saito, Hirohide
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016789/
https://ncbi.nlm.nih.gov/pubmed/27608814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32532
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