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Monooxygenase Substrates Mimic Flavin to Catalyze Cofactorless Oxygenations

Members of the antibiotic biosynthesis monooxygenase family catalyze O(2)-dependent oxidations and oxygenations in the absence of any metallo- or organic cofactor. How these enzymes surmount the kinetic barrier to reactions between singlet substrates and triplet O(2) is unclear, but the reactions ha...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Machovina, Melodie M., Usselman, Robert J., DuBois, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016173/
https://ncbi.nlm.nih.gov/pubmed/27307041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.730051
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