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Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy

Bacterial topoisomerases are attractive antibacterial drug targets because of their importance in bacterial growth and low homology with other human topoisomerases. Structure-based drug design has been a proven approach of efficiently developing new antibiotics against these targets. Past studies ha...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Li, Yan, Wong, Ying Lei, Ng, Fui Mee, Liu, Boping, Wong, Yun Xuan, Poh, Zhi Ying, Liu, Shuang, Then, Siew Wen, Lee, Michelle Yueqi, Ng, Hui Qi, Huang, Qiwei, Hung, Alvin W., Cherian, Joseph, Hill, Jeffrey, Keller, Thomas H., Kang, CongBao
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016168/
https://ncbi.nlm.nih.gov/pubmed/27365392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737429
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