Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy

Bacterial topoisomerases are attractive antibacterial drug targets because of their importance in bacterial growth and low homology with other human topoisomerases. Structure-based drug design has been a proven approach of efficiently developing new antibiotics against these targets. Past studies ha...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Li, Yan, Wong, Ying Lei, Ng, Fui Mee, Liu, Boping, Wong, Yun Xuan, Poh, Zhi Ying, Liu, Shuang, Then, Siew Wen, Lee, Michelle Yueqi, Ng, Hui Qi, Huang, Qiwei, Hung, Alvin W., Cherian, Joseph, Hill, Jeffrey, Keller, Thomas H., Kang, CongBao
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016168/
https://ncbi.nlm.nih.gov/pubmed/27365392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737429
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