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Pepsin-Containing Membranes for Controlled Monoclonal Antibody Digestion Prior to Mass Spectrometry Analysis

Monoclonal antibodies (mAbs) are the fastest growing class of therapeutic drugs, because of their high specificities to target cells. Facile analysis of therapeutic mAbs and their post-translational modifications (PTMs) is essential for quality control, and mass spectrometry (MS) is the most powerfu...

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Vydáno v:Anal Chem
Hlavní autoři: Pang, Yongle, Wang, Wei-Han, Reid, Gavin E., Hunt, Donald F., Bruening, Merlin L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016144/
https://ncbi.nlm.nih.gov/pubmed/26455365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.5b02739
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