Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM

Macrophage CD36 binds and internalizes oxidized low density lipoprotein (oxLDL) to facilitate foam cell formation. CD36 expression is activated by peroxisome proliferator-activated receptor γ (PPARγ). Tamoxifen, an anti-breast cancer medicine, has demonstrated pleiotropic functions including cardiop...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Yu, Miao, Jiang, Meixiu, Chen, Yuanli, Zhang, Shuang, Zhang, Wenwen, Yang, Xiaoxiao, Li, Xiaoju, Li, Yan, Duan, Shengzhong, Han, Jihong, Duan, Yajun
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016103/
https://ncbi.nlm.nih.gov/pubmed/27358406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740092
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