Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3

The complement system is an important part of the innate immune response to infection but may also cause severe complications during inflammation. Small molecule antagonists to complement receptor 3 (CR3) have been widely sought, but a structural basis for their mode of action is not available. We r...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jensen, Maria Risager, Bajic, Goran, Zhang, Xianwei, Laustsen, Anne Kjær, Koldsø, Heidi, Skeby, Katrine Kirkeby, Schiøtt, Birgit, Andersen, Gregers R., Vorup-Jensen, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016102/
https://ncbi.nlm.nih.gov/pubmed/27339893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.732222
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