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IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives
Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. IDH1/2 mutations define distinct subsets of cancers, including low-grade gliomas and secondary glioblastomas, chondrosarcomas, intrahepatic cholangiocarcinomas, and hematologic mali...
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| 出版年: | J Blood Med |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Dove Medical Press
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5015873/ https://ncbi.nlm.nih.gov/pubmed/27621679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JBM.S70716 |
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