Amyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease

The mechanisms leading to amyloid-β (Aβ) accumulation in sporadic Alzheimer disease (AD) are unknown but both increased production or impaired clearance likely contribute to aggregation. To understand the potential roles of the extracellular matrix proteoglycan Testican-1 in the pathophysiology of A...

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Veröffentlicht in:J Neuropathol Exp Neurol
Hauptverfasser: Barrera-Ocampo, Alvaro, Arlt, Sönke, Matschke, Jakob, Hartmann, Ursula, Puig, Berta, Ferrer, Isidre, Zürbig, Petra, Glatzel, Markus, Sepulveda-Falla, Diego, Jahn, Holger
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015660/
https://ncbi.nlm.nih.gov/pubmed/27486134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nlw065
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