Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure

BACKGROUND: Metabolic impairment is an important contributor to heart failure (HF) pathogenesis and progression. Dysregulated metabolic pathways remain poorly characterized in patients with HF and preserved ejection fraction (HFpEF). We sought to determine metabolic abnormalities in HFpEF and identi...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Hunter, Wynn G., Kelly, Jacob P., McGarrah, Robert W., Khouri, Michel G., Craig, Damian, Haynes, Carol, Ilkayeva, Olga, Stevens, Robert D., Bain, James R., Muehlbauer, Michael J., Newgard, Christopher B., Felker, G. Michael, Hernandez, Adrian F., Velazquez, Eric J., Kraus, William E., Shah, Svati H.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015273/
https://ncbi.nlm.nih.gov/pubmed/27473038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.003190
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