Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)

Mature thrombin activatable fibrinolysis inhibitor (TAFIa) is a carboxypeptidase that stabilizes fibrin clots by removing C-terminal arginines and lysines from partially degraded fibrin. Inhibition of TAFIa stimulates the degradation of fibrin clots and may help to prevent thrombosis. Applying a lea...

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Udgivet i:Sci Rep
Main Authors: Schreuder, Herman, Liesum, Alexander, Lönze, Petra, Stump, Heike, Hoffmann, Holger, Schiell, Matthias, Kurz, Michael, Toti, Luigi, Bauer, Armin, Kallus, Christopher, Klemke-Jahn, Christine, Czech, Jörg, Kramer, Dan, Enke, Heike, Niedermeyer, Timo H. J., Morrison, Vincent, Kumar, Vasant, Brönstrup, Mark
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015106/
https://ncbi.nlm.nih.gov/pubmed/27604544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32958
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