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Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

Cancer cells have altered metabolism compared to normal cells, including dependence on glutamine (GLN) for survival, known as GLN addiction. However, some cancer cell lines do not require GLN for survival and the basis for this discrepancy is not well understood. GLN is a precursor for antioxidants...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Cetinbas, Naniye Mallı, Sudderth, Jessica, Harris, Robert C., Cebeci, Aysun, Negri, Gian L., Yılmaz, Ömer H., DeBerardinis, Ralph J., Sorensen, Poul H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015067/
https://ncbi.nlm.nih.gov/pubmed/27605385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32606
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