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Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

Cancer cells have altered metabolism compared to normal cells, including dependence on glutamine (GLN) for survival, known as GLN addiction. However, some cancer cell lines do not require GLN for survival and the basis for this discrepancy is not well understood. GLN is a precursor for antioxidants...

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Publicat a:Sci Rep
Autors principals: Cetinbas, Naniye Mallı, Sudderth, Jessica, Harris, Robert C., Cebeci, Aysun, Negri, Gian L., Yılmaz, Ömer H., DeBerardinis, Ralph J., Sorensen, Poul H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015067/
https://ncbi.nlm.nih.gov/pubmed/27605385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32606
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