Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor

BACKGROUND AND OBJECTIVES: Obesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity. We hypothesize that cathelicidin expression correlates with obesity and modulates fat mass and hepa...

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Publié dans:Int J Obes (Lond)
Auteurs principaux: Tran, Deanna Hoang-Yen, Tran, Diana Hoang-Ngoc, Mattai, S. Anjani, Sallam, Tamer, Ortiz, Christina, Lee, Elaine C., Robbins, Lori, Ho, Samantha, Lee, Jung Eun, Fisseha, Elizabeth, Shieh, Christine, Sideri, Aristea, Shih, David Q, Fleshner, Philip, McGovern, Dermot PB, Vu, Michelle, Hing, Tressia C., Bakirtzi, Kyriaki, Cheng, Michelle, Su, Bowei, Law, Ivy, Karagiannides, Iordanes, Targan, Stephan R., Gallo, Richard L., Li, Zhaoping, Koon, Hon Wai
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014693/
https://ncbi.nlm.nih.gov/pubmed/27163748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ijo.2016.90
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