Substance P Mediates Proinflammatory Cytokine Release From Mesenteric Adipocytes in Inflammatory Bowel Disease Patients

BACKGROUND & AIMS: Substance P (SP) neurokinin-1 receptors (NK-1Rs) are expressed in mesenteric preadipocytes, and SP binding activates proinflammatory signaling in these cells. We evaluated the expression levels of SP (Tac-1), NK-1R (Tacr-1), and NK-2R (Tacr-2) mRNA in preadipocytes isolated fr...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Sideri, Aristea, Bakirtzi, Kyriaki, Shih, David Q., Koon, Hon Wai, Fleshner, Phillip, Arsenescu, Razvan, Arsenescu, Violeta, Turner, Jerrold R., Karagiannides, Iordanes, Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629258/
https://ncbi.nlm.nih.gov/pubmed/26543894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.03.003
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