TGFβ1-Induced PAI-1 Contributes to a Pro-Fibrotic Network in Eosinophilic Esophagitis

BACKGROUND: Eosinophilic esophagitis is an allergic disease of increasing worldwide incidence. Complications are due to tissue remodeling and involve transforming growth factor-β1 (TGFβ1) mediated fibrosis. Plasminogen Activator Inhibitor-1 (PAI-1/serpinE1) can be induced by TGFβ1 but its role in Eo...

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Publicado no:J Allergy Clin Immunol
Main Authors: Rawson, Renee, Yang, Tom, Newbury, Robert O., Aquino, Melissa, Doshi, Ashmi, Bell, Braxton, Broide, David H., Dohil, Ranjan, Kurten, Richard, Aceves, Seema S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014565/
https://ncbi.nlm.nih.gov/pubmed/27212082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.02.028
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