Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

Applications of RNA interference for neuroscience research have been limited by a lack of simple and efficient methods to deliver oligonucleotides to primary neurons in culture and to the brain. Here, we show that primary neurons rapidly internalize hydrophobically modified siRNAs (hsiRNAs) added di...

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書目詳細資料
發表在:Mol Ther Nucleic Acids
Main Authors: Alterman, Julia F, Hall, Lauren M, Coles, Andrew H, Hassler, Matthew R, Didiot, Marie-Cecile, Chase, Kathryn, Abraham, Jasmin, Sottosanti, Emily, Johnson, Emily, Sapp, Ellen, Osborn, Maire F, Difiglia, Marian, Aronin, Neil, Khvorova, Anastasia
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014532/
https://ncbi.nlm.nih.gov/pubmed/26623938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.38
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