A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy

Epidermolytic palmoplantar keratoderma (EPPK) is a relatively common autosomal-dominant skin disorder caused by mutations in the keratin 9 gene (KRT9), with few therapeutic options for the affected so far. Here, we report a knock-in transgenic mouse model that carried a small insertion–deletion (ind...

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發表在:Mol Ther Nucleic Acids
Main Authors: Lyu, Ya-Su, Shi, Pei-liang, Chen, Xiao-Ling, Tang, Yue-Xiao, Wang, Yan-Fang, Liu, Rong-Rong, Luan, Xiao-Rui, Fang, Yu, Mei, Ru-Huan, Du, Zhen-Fang, Ke, Hai-Ping, Matro, Erik, Li, Ling-En, Lin, Zhao-Yu, Zhao, Jing, Gao, Xiang, Zhang, Xian-Ning
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014458/
https://ncbi.nlm.nih.gov/pubmed/27003758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.17
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