CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse

CRISPR/Cas9 has been confirmed as a distinctly efficient, simple-to-configure, highly specific genome-editing tool that has been used to treat monogenetic disorders. Epidermolytic palmoplantar keratoderma (EPPK) is a common autosomal dominant keratin disease resulting from dominant-negative mutation...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Luan, Xiao-Rui, Chen, Xiao-Ling, Tang, Yue-Xiao, Zhang, Jin-Yan, Gao, Xiang, Ke, Hai-Ping, Lin, Zhao-Yu, Zhang, Xian-Ning
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023945/
https://ncbi.nlm.nih.gov/pubmed/30195761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.05.005
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