A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA

Hepatitis B virus (HBV) infection is a major cause of chronic active hepatitis, cirrhosis, and primary hepatocellular carcinoma, all of which are severe threats to human health. However, current clinical therapies for HBV are limited by potential side effects, toxicity, and drug-resistance. In this...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Zeng, Zhengyang, Han, Shisong, Hong, Wei, Lang, Yange, Li, Fangfang, Liu, Yongxiang, Li, Zeyong, Wu, Yingliang, Li, Wenxin, Zhang, Xianzheng, Cao, Zhijian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014453/
https://ncbi.nlm.nih.gov/pubmed/26978579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.11
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