A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA

Hepatitis B virus (HBV) infection is a major cause of chronic active hepatitis, cirrhosis, and primary hepatocellular carcinoma, all of which are severe threats to human health. However, current clinical therapies for HBV are limited by potential side effects, toxicity, and drug-resistance. In this...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther Nucleic Acids
Prif Awduron: Zeng, Zhengyang, Han, Shisong, Hong, Wei, Lang, Yange, Li, Fangfang, Liu, Yongxiang, Li, Zeyong, Wu, Yingliang, Li, Wenxin, Zhang, Xianzheng, Cao, Zhijian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014453/
https://ncbi.nlm.nih.gov/pubmed/26978579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.11
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