Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway

BACKGROUND: Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation of free cholesterol in lysosomes. There are currently no effective FDA-approved treatments for NPC, although in the last years the inhibition of Histone Deacetylases (HDACs) has emer...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Contreras, Pablo S., Gonzalez-Zuñiga, Marcelo, González-Hódar, Lila, Yáñez, María José, Dulcey, Andrés, Marugan, Juan, Seto, Edward, Alvarez, Alejandra R., Zanlungo, Silvana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014229/
https://ncbi.nlm.nih.gov/pubmed/26603102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2015.11.006
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