Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson’s disease: a dose-finding study

In advanced stages of Parkinson’s disease, serotonergic terminals take up l-DOPA and convert it to dopamine. Abnormally released dopamine may participate in the development of l-DOPA-induced dyskinesias. Simultaneous activation of 5-HT1A and 5-HT1B receptors effectively blocks l-DOPA-induced dyskine...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Svenningsson, Per, Rosenblad, Carl, af Edholm Arvidsson, Karolina, Wictorin, Klas, Keywood, Charlotte, Shankar, Bavani, Lowe, David A., Björklund, Anders, Widner, Håkan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014080/
https://ncbi.nlm.nih.gov/pubmed/25669730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu409
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