Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals

The vesicular monoamine transporter 2 (VMAT2) packages neurotransmitters for release during neurotransmission and sequesters toxicants into vesicles to prevent neuronal damage. In mice, low VMAT2 levels causes catecholaminergic cell loss and behaviors resembling Parkinson’s disease, while high level...

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Detalles Bibliográficos
Publicado en:Toxicol Sci
Main Authors: Lohr, Kelly M., Chen, Merry, Hoffman, Carlie A., McDaniel, Miranda J., Stout, Kristen A., Dunn, Amy R., Wang, Minzheng, Bernstein, Alison I., Miller, Gary W.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
Assuntos:
Vesicular Transport and Dopamine Toxicity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013878/
https://ncbi.nlm.nih.gov/pubmed/27287315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw106
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