Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock

Although food availability is a potent synchronizer of the peripheral circadian clock in mammals, the underlying mechanisms are unclear. Here, we show that hepatic Bmal1, a core transcription activator of the molecular clock, is post-transcriptionally regulated by signals from insulin, an important...

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Udgivet i:Nat Commun
Main Authors: Dang, Fabin, Sun, Xiujie, Ma, Xiang, Wu, Rong, Zhang, Deyi, Chen, Yaqiong, Xu, Qian, Wu, Yuting, Liu, Yi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013695/
https://ncbi.nlm.nih.gov/pubmed/27576939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12696
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