Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study

BACKGROUND: Higher latitude and human leukocyte antigen (HLA)-DRB1*04:05 increase susceptibility to multiple sclerosis (MS) in the Japanese population, but their effects on disease severity are unknown. We aimed to clarify the effects of latitude and the HLA-DRB1 and HLA-DPB1 genes on disease severi...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Nakamura, Yuri, Matsushita, Takuya, Sato, Shinya, Niino, Masaaki, Fukazawa, Toshiyuki, Yoshimura, Satoshi, Hisahara, Shin, Isobe, Noriko, Shimohama, Shun, Watanabe, Mitsuru, Yoshida, Kazuto, Houzen, Hideki, Miyazaki, Yusei, Yamasaki, Ryo, Kikuchi, Seiji, Kira, Jun-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013608/
https://ncbi.nlm.nih.gov/pubmed/27599848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0695-3
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