New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study

BACKGROUND: The antimalarial drug Pyrimethamine has been suggested to exert an antitumor activity by inducing apoptotic cell death in cancer cells, including metastatic melanoma cells. However, the dose of Pyrimethamine to be considered as an anticancer agent appears to be significantly higher than...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Tommasino, Chiara, Gambardella, Lucrezia, Buoncervello, Maria, Griffin, Roger J., Golding, Bernard T., Alberton, Manuela, Macchia, Daniele, Spada, Massimo, Cerbelli, Bruna, d’Amati, Giulia, Malorni, Walter, Gabriele, Lucia, Giammarioli, Anna Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013574/
https://ncbi.nlm.nih.gov/pubmed/27599543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0409-9
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