New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study

BACKGROUND: The antimalarial drug Pyrimethamine has been suggested to exert an antitumor activity by inducing apoptotic cell death in cancer cells, including metastatic melanoma cells. However, the dose of Pyrimethamine to be considered as an anticancer agent appears to be significantly higher than...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Tommasino, Chiara, Gambardella, Lucrezia, Buoncervello, Maria, Griffin, Roger J., Golding, Bernard T., Alberton, Manuela, Macchia, Daniele, Spada, Massimo, Cerbelli, Bruna, d’Amati, Giulia, Malorni, Walter, Gabriele, Lucia, Giammarioli, Anna Maria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013574/
https://ncbi.nlm.nih.gov/pubmed/27599543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0409-9
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